Her successful solo career has spanned several decades with several Grammy nominations, two Grammy award and the release of nine critically acclaimed solo albums, including the profoundly popular soundtrack for the film Magnolia, which garnered an Academy Award and Golden Globe nomination for Best Song in 2000.  Time magazine has said, “Mann has the same skill that great tunesmiths like McCartney and Neil Young have: the knack for writing simple, beautiful, instantly engaging songs, ” while NPR voted her one of the “TOP 10 Best Living Songwriters” along with Paul McCartney, Bob Dylan, and Bruce Springsteen. Her latest release is called "Mental Illness" which won her a Grammy for Best Folk Album.

Earlier in her musical life, Mann fronted the band “Til Tuesday”, releasing three albums. She has also made numerous memorable cameo appearances in films such as The Big Lebowski and TV shows like Portlandia and The Daily Show.